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Moreover, use of systemic steroids for psoriasis has not been decreasing since the introduction of biologics for psoriasis(9), or it has increased in the last few years. It is clear that there is no indication for discontinuing drugs used for the treatment of psoriasis. Conclusion Psoriasis affects ∼300 million citizens worldwide, and is the third leading cause of noncommunicable disease . Despite the extensive research, the development of effective therapies for psoriasis remains a problem of immense importance. Psoriasis is an inflammatory skin disease in which erythema (lightening) and hyperkeratoses (scarring) form as the result of excessive accumulation of inflammatory cells, the primary cause of psoralinic eruption. The pathogenesis of psoriasis is complex, but some of the major histological changes are related to immune activation. Thus, a change in the immune environment has been identified in the etiology of psoriasis as the cause of various inflammatory manifestations, which lead to their progression in the body . With its many similarities, psoriasis is considered as a comorbidity of different conditions. The aim of the present study was to determine the efficacy and safety of topical antibiotics in patients with active psoriasis. The results of this study demonstrate that the use of systemic antibiotics for treating psoriasis should be considered, and the use of systemic antibiotics in patients with inactive psoriasis should be considered in all cases where psoriasis is suspected. Similar articles: